Freak Science: Antioxidant Flavonoids and our Aerobic Training Shake
Endurance, the ability to sustain physical activity for prolonged periods, is a critical component of fitness, particularly in sports like distance running, cycling, swimming, cross country skiing and rowing. While training, sports nutrition, and genetics all impact an individual’s endurance capacity, research suggests that flavonoids, a specific group of antioxidant compounds found in various plant-based foods like cocoa and tea, could play a pivotal role in endurance performance.
Flavonoids are a subclass of polyphenols, a diverse group of over 8,000 naturally occurring compounds found in fruits, vegetables, tea, fruits and berries, red wine, and cocoa. Many of the “Super Food” trends have hung their hats on various health benefits linked to this diverse set of naturally occurring compounds. Cocoa in particular, is rich in an even more specific subclass of antioxidant flavonoids known as catechins. It’s Catechins that have garnered attention for their potential to positively impact endurance.
Catechins are also where the Freak Shake Endurance Fuel began. Over the last 10 years, we became very interested in the growing body of evidence linking these flavonoids to the underlying biological systems that support exercise and physical conditioning. And so when we designed our first sports nutrition drink, it started with the idea that every serving of Freak Shake would be fortified with a functional amount of these special antioxidants. In fact, each serving of Freak Shake contains an equivalent amount of catechins to 2oz of natural cocoa powder - about a quarter of an 8oz canister!
Mitochondrial Function and Endurance:
At the heart of endurance lies mitochondrial function. Mitochondria are the cellular powerhouses responsible for generating adenosine triphosphate (ATP), the energy currency of cells. During endurance exercise, the muscle demand for ATP increases significantly, requiring optimal mitochondrial function to meet this need. Here lies the connection between Freak Shake’s antioxidants and endurance: Our flavonoids have been demonstrated to influence mitochondrial function, thus impacting the body’s ability to sustain prolonged physical activity.
1. Enhancing Mitochondrial Biogenesis:
Catechins have been found to stimulate pathways involved in mitochondrial biogenesis, the process by which new mitochondria are produced within cells. One key player in this process is the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), a master regulator of mitochondrial biogenesis. Flavonoids, through their influence on signaling pathways, may activate PGC-1α and promote the creation of new mitochondria. This increase in mitochondrial density can enhance the muscle cells’ capacity to produce ATP, consequently improving endurance performance.
2. Improved Mitochondrial Efficiency:
Flavonoids’ impact on mitochondrial function extends beyond mere quantity. Research suggests that these compounds can improve the efficiency of mitochondrial respiration—the process by which mitochondria produce ATP. Flavonoids’ antioxidant properties play a role here, as they help combat oxidative stress within mitochondria. By reducing oxidative damage, antioxidant flavonoids help maintain the integrity of the electron transport chain, allowing for more efficient ATP production during endurance activities.
3. Enhanced Oxygen Utilization:
Another factor that can limit endurance is the body’s ability to efficiently use oxygen. Flavonoids may positively influence our capacity to utilize oxygen by promoting vasodilation—the widening of blood vessels—which results in improved blood flow. Enhanced blood flow means more oxygen-rich blood reaches working muscles, which is crucial for maintaining aerobic energy production in the mitochondria during endurance exercise. Improved oxygen delivery translates to delayed fatigue and improved endurance capacity.
4. Delayed Muscle Fatigue:
Flavonoids’ impact isn’t limited to the cellular level; they also influence the neuromuscular junction, the point where nerve signals meet muscle contractions. Flavonoids’ antioxidant properties can reduce oxidative stress at the neuromuscular junction, potentially delaying the onset of muscle fatigue. This effect is particularly relevant in endurance activities where maintaining proper neuromuscular communication is vital for sustained effort.
5. Anti-Inflammatory Effects:
Endurance exercise, especially at high intensities, can induce inflammation and oxidative stress. Flavonoids’ anti-inflammatory properties can help mitigate this response, minimizing tissue damage and aiding in post-exercise recovery. By reducing the extent of exercise-induced inflammation, flavonoids contribute to a more optimal environment for endurance training adaptation.
Why Freak Shake?
Endurance is multifaceted. Our level of endurance relies on efficient energy production, oxygen utilization, and muscle function. Antioxidant flavonoids, through their influence on mitochondrial biogenesis, mitochondrial efficiency, oxygen delivery, and anti-inflammatory effects, have the potential to positively impact endurance performance.
For athletes and individuals seeking to enhance their endurance capability, the incorporation of flavonoid-rich foods into their diets may help optimize their exercise and ultimately competitive performance. Our elite fuel for endurance is not just a complete endurance drink, but it is fortified with a concentrated dose of these multifaceted flavonoids. This makes Freak Shake a unique pre or post workout drink to compliment your endurance training.
You train freak’n hard. The level of commitment can seem absurd sometimes! With so much energy invested into doing what you love, why not try incorporating Freak Shake Endurance Fuel or Grit Fuel antioxidant capsules into your sports nutrition program and explore these benefits for yourself?
Try some!!!!

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